Pre-clinical and clinical trials

PlasmAcute's preclinical and clinical development collaborations:

National Institute for Communicable Diseases, Sexually Transmitted Infections Reference center, Johannesburg, South Africa.
Early detection of HIV-1 specific lymphocyte derived antibodies in a high risk population, and early detection of HIV 1-2 antibodies in South African blood donors using the PA technology. Poster presentation at the STDR meeting in Seattle, July 2007. A full size publication has been submitted to a leading journal.
Principal Investigator: Professor Dr. David Lewis

University of Cambridge, UK
University of Ghana
Detection and kinetics of antibody production in the early stages of immunization with Hepatitis B vaccine, to assess the usefulness of the PlasmAcute technology in Hepatitis B vaccine monitoring. Published in Clinical and Vaccine Immunology, 10 Oct 2007. See abstract.
Principal investigator: Professor Dr. Jean-Pierre Allain

University of Bergen, Department of Microbiology and Immunology, Norway
Influenza Vaccine Trial. Detection of B-cell antibodies before seroconversion in vaccinated volunteers. Published at the International Congress Series 1219 (2001), 283-289. See article.
Principal investigator: Professor Dr. Lars Haaheim.

National Institute for Communicable Diseases, Sexually Transmitted Infections Reference Center, Johannesburg, South Africa
University of Johannesburg, Sexually Transmitted Disease Clinic, South Africa
HIV-antibodies in the B-cells and in the serum in women at high risk in South Africa. GCP conform prospective human trial to determine earlier detection of HIV in B-cell lysate as compared to conventional testing in plasma. Currently ongoing.
Principal investigator: Professor Dr. David Lewis

Imperial College of London, Department of Virology, UK
Trial investigating basic biochemical markers of the immune response, to investigate the basic performance characteristics of the PlasmAcute technology in native B-cells and B-cell lines, and to investigate an antihuman assay format and establish a multiplexing format. Currently ongoing.
Principal investigators: Professor Myra McClure, Dr. David Jefferies

Red Cross Blood Bank, Frankfurt, Germany
University of Frankfurt, Department of Hematology and Infectiology, Germany
Trial on acute / critical blood samples, covering HIV, Hepatitis B virus, Eppstein Barr virus, Cytomegalovirus, Herpes Simplex Encephalitis, Chlamydia, Syphilis, Dengue, West-Nile, Lassa virus, Lyme disease, autoimmune diseases, fever of unknown origin and immunocompromised patients. Currently ongoing.
Principal investigators: Professor Dr. Brodt, PD Dr. Michael Schmidt.

University of Leipzig, Department of Immunology, Germany
Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany
Mouse trial to investigate the time course of infective parameters in different compartments of the blood in mice after a controlled infection. Currently ongoing.
Principal investigators: PD Dr. Reinhard Straubinger, Dr. Jörg Lehman

Friedrich-Löffler Institute, Greifswald, Insel Riems, Germany
Trials to test the PlasmAcute technology in terms of earlier diagnosis in classical swine fever, foot and mouth disease, blue tongue disease and bird flu. Currently ongoing
Principal investigator: PD Dr. Martin Beer